‘Sure, that may be about appropriate. I try to find a physical idea of biological programs in a bottom-up way. I feel you could potentially distinguish a few strains of study in my team for the time being. The 1st issues chromosome construction: how do you get a metre-extended DNA polymer folded and organised in this type of microscopic cell? We now have made visualisation methods that enable us to review how, for instance, SMC proteins loop DNA (video clip on Youtube) in an effort to Establish up chromosomes.
Our group scientific studies bacterial cell division and it is aiming to constitute a ‘base up biology’ in synthetic cells that could autonomously divide. Our key fascination lies in cell division, chromatin structure, and spatial control.
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Nanofabrication of electrodes with sub-five nm spacing for transportation experiments on solitary molecules and metallic clusters
We create point-of-care diagnostics take a look at of neglected tropical conditions inside of resource-confined options, determined by Crspr/Cas9 detecting of pathogen’s DNA in physique fluids.
Instance (three) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is shown in gray, the rim on the pore is highlighted in crimson, and a 3D rendering of your movement from the DNA rod is exhibited.
We shape bacteria into forms that deviate from their all-natural phenotype. Specifically, I'll exhibit our capacity to form live E. coli bacteria into novel styles for example rectangles, squares, triangles and circles.
He also discovered time to put in writing a number of textbooks, send Practically forty thousand tweets and lead An effective investigate group at Delft College of Technology. ‘It doesn’t come to feel like work’, he states. ‘I’m https://www.ceesdekker.net just terribly curious.’
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Dekker started his exploration on solitary carbon nanotubes in 1993 when he set up a new line of investigate to review electrical transport by single natural and organic molecules amongst nanoelectrodes. In 1996 a breakthrough was realized with carbon nanotubes. This was realized within a collaboration Using the team of Nobel laureate Richard Smalley. STM and nanolithography strategies were being accustomed to demonstrate that these nanotubes are quantum wires at The only-molecule level, with remarkable physical Houses.
Given that 2000 he moved to single-molecule biophysics and nanobiology, with exploration from scientific studies of DNA loop extrusion and supercoiling to DNA translocation through nanopores. Additional not too long ago his study has centered on learning chromatin composition and cell division with microbes on chip, although he is also aiming to ultimately Make synthetic cells from The underside up.
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Lastly, I will briefly sketch a number of our Concepts to examine the setting up of artificial cells, specifically our initial actions to ascertain synthetic cell division.